Double muscling in cattle due to mutations in the myostatin gene
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چکیده
منابع مشابه
Myostatin Mutations Cause Double Muscling in Cattle
The differences between humans and farm animals are obvious, from body structure to diet to reproduction. Unlike humans, swine have litters of young; cattle are ruminants; and sheep are woolly. Despite such significant differences, growth and development of mammalian species is very similar. The biological controls that govern the establishment of body axes, induction and morphogenesis of tissu...
متن کاملDouble muscling in cattle due to mutations in the myostatin gene.
Myostatin (GDF-8) is a member of the transforming growth factor beta superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass in mice. Here we report the myostatin sequences of nine other vertebrate species and the identification of mutations in the coding sequence of bovine myostatin in two breeds of double-muscled cattle, Belgi...
متن کاملConvenient genotyping of six myostatin mutations causing double-muscling in cattle using a multiplex oligonucleotide ligation assay.
We herein describe a procedure that allows for simultaneous genotyping of six loss-of-function mutations in the bovine myostatin gene associated with the double-muscling phenotype. The proposed method relies on a multiplex oligonucleotide ligation assay and detection of the fluorescently labelled products using automatic sequencers.
متن کاملDouble Muscling in Cattle: Genes, Husbandry, Carcasses and Meat
Molecular biology has enabled the identification of the mechanisms whereby inactive myostatin increases skeletal muscle growth in double-muscled (DM) animals. Myostatin is a secreted growth differentiation factor belonging to the transforming growth factor-β superfamily. Mutations make the myostatin gene inactive, resulting in muscle hypertrophy. The relationship between the different character...
متن کاملMutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle.
A visibly distinct muscular hypertrophy (mh), commonly known as double muscling, occurs with high frequency in the Belgian Blue and Piedmontese cattle breeds. The autosomal recessive mh locus causing double-muscling condition in these cattle maps to bovine chromosome 2 within the same interval as myostatin, a member of the TGF-beta superfamily of genes. Because targeted disruption of myostatin ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1997
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.94.23.12457